The article with the second highest citation density, i.e., 18.07, was a clinical trial written by Boyne et al., in 2005 [61]. RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 (rh BMP-2)Infuse TM Bone Graft contains a manufactured bone graft material that is approved for use as a bone graft in sinus augmentation and localized alveolar ridge augmentation. There is a need for further studies to develop novel biomaterials for BMP delivery in such applications as periodontal and craniofacial applications and in dentin regeneration in teeth. The citation counts for the top 50 publications ranged from 81 to 557 (median 113.5). This bibliometric analysis is aimed at identifying and analyzing the top 50 most-cited articles on the dental applications of BMPs. % Objects: 1198 The Visualization of Similarities viewer (VOSviewer) software [57] was used to create collaboration network maps regarding the cooccurrences of all keywords. This trend of publication highlights the influence of the impact factor of a journal and the inclination of authors to cite and article that is published in a high impact factor journal within a given specialty. Highly cited studies indicate the research interests of certain periods, and high-frequency keywords reflect the hot topics within research [49]. Bone morphogenic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone. Bone Morphogenetic Protein. /C [0 0 1] Bone morphogenetic proteins (BMPs) are suggested to have therapeutic potential to enhance fracture healing in such patients. Furthermore, if two or more articles had the same citation count, the article with the higher citation density was ranked higher. Its calculation follows the following formula: citations from journal citation report (JCR) year of documents published in the last 5 years, divided by the total number of citable documents [, CiteScore (CS): this is a newly introduced indicator adopted to assess the impact of journals so that more rigorous results can be obtained. Present Status of Bone Morphogenetic Proteins in Dentistry: Koudale, Somnath, Bhongade, Monohar, Deshpande, Aniruddha: Amazon.sg: Books Abstract. The sponge is then designed to resorb, or disappear, over time. The majority of the contributions were made by Wikesjö UM (, 1430 citations), followed by Wozney JM (, 1376), Lilly LC (, 992), Cochrane DL (, 866), Rohrer MD (, 578), Jones AA (, 775), and Boyne PJ (, 717) (Figure 3). We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. The authors have no conflict of interest to disclose. Bibliometric analysis is helpful to determine the most influential studies in a specific field. Articles on the application for BMPs in dentistry were collected from the Dentistry, Oral Surgery, and Medicine Category of the Clarivate Analytics’ Web of Science (WoS), considering the “All Databases” section. As the sponge dissolves, the bone morphogenetic protein stimulates the cells to produce new bone. Van Eck and L. Waltman, “Software survey: VOSviewer, a computer program for bibliometric mapping,”, J. P. Fiorellini, T. H. Howell, D. Cochran et al., “Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation,”, K. Iohara, M. Nakashima, M. Ito, M. Ishikawa, A. Nakasima, and A. Akamine, “Dentin regeneration by dental pulp stem cell therapy with recombinant human bone morphogenetic protein 2,”, R. E. Jung, R. Glauser, P. Schärer, C. H. F. Hämmerle, H. F. Sailer, and F. E. Weber, “Effect of rhBMP-2 on guided bone regeneration in humans,”, P. J. Boyne, L. C. Lilly, R. E. Marx et al., “De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation,”, R. G. Triplett, M. Nevins, R. E. Marx et al., “Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for maxillary sinus floor augmentation,”, M. Cicciù, A. Scott, D. Cicciù, R. Tandon, and C. Maiorana, “Recombinant human bone morphogenetic protein-2 promote and stabilize hard and soft tissue healing for large mandibular new bone reconstruction defects,”, A. Fardi, K. Kodonas, T. Lillis, and A. Veis, “Top-cited articles in implant dentistry,”, P. Ahmad, P. M. H. Dummer, T. Y. Noorani, and J. This led to it being the most widely used BMP-type worldwide. Bone morphogentic protein 1. Similarly, the 3rd and 4th positions are achieved by articles that were published in 2004 [59] and 2005 [61], securing 261 and 253 citations, respectively. Bone morphogenic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone. Based on normality and distribution of the data, the mean (standard deviation) or median (interquartile range) was calculated. We are committed to sharing findings related to COVID-19 as quickly as possible. 1 0 obj % PdfSharp.Pdf.PdfDictionary Importantly, a lack of multicenter studies was noteworthy, reflecting a need to escalate the international collaboration. Introduction. However, in the recent years, an increased average number of authors per article have been reported, a progress that corresponds to other medical specialties because of the multidisciplinary nature of much recent research activity [82]. The sponge is then designed to resorb, or disappear, over time. >> IBM SPSS Statistics version 24.0 (IBM, Chicago, IL) was used to perform descriptive and bivariate analyses. To investigate the feasibility and efficacy of this gene‐activated scaffold on dental tissue engineering, human dental pulp stem cells (DPSCs) were seeded in this scaffold for in vitro and in vivo study. Bone Morphogenetic Protein. Bone morphogenetic proteins (BMPs) are a group of regulatory glycoproteins that are members of the transforming growth factor-beta superfamily. As the sponge dissolves, the bone morphogenetic protein stimulates the cells to produce new bone. While only a small amount of BMP is produced naturally, lab-derived proteins can be produced at significantly higher quantities and be used to aid in the body’s own healing process after surgery. Several bibliometric studies have reported that authors hailing from institutions of Asia and Africa whether being the first or the corresponding authors made an almost negligible contribution which could be regarded as the “classic article” [76, 83, 88, 90, 91]. Bone Morphogenetic Protein. A statistically nonsignificant trend () was observed between a journal age and the number of “classic” articles published in that journal. Dr. S.M. Bone induction is a sequential multistep cascade. Perhaps, the most important reason is that it would be ethically wrong to intentionally subject humans to health risks for observing the course of the disease [93]. The most frequently used keyword was bone regeneration (n =23), followed by bone morphogenetic protein (), animal studies (), tissue engineering (), dental implants (), periodontal regeneration (), protein (), bone morphogenetic protein-2 (), and growth factor (). Supplementary Table 1 depicts the principal characteristics of the top 50 most-cited articles. A scientific paper having received more than 400 citations is believed by some to be a “classic” article [45]; however, based on the field of research, an article having secured 100 or more citations can also be considered a “classic” [44, 51, 52]. Using Bone Morphogenetic Protein to Generate Bone4 54 Deliberate design of procedures to exploit the healing mech- anism of BMPs can improve the outcome of treatment. (2)CiteScore (CS): this is a newly introduced indicator adopted to assess the impact of journals so that more rigorous results can be obtained. Bone morphogenetic protein-7 (BMP-7) has been shown to inhibit liver and renal fibrosis in in vivo and vitro studies. T1 - The application of bone morphogenetic proteins to dental tissue engineering. /BaseFont /OSFJYE+MinionPro-Regular The sponge is then designed to resorb, or disappear, over time. In contrast, the bone morphogenetic proteins (BMPs) represent a unique set of differentiation factors that induce new bone formation at the site of implantation instead of changing the growth rate of pre‐existing bone. In the current study, we used the rat model to explore the potential antifibrotic role of BMP-7 and its underlying mechanism in silica-induced pulmonary fibrosis. In oral and maxillofacial surgery, BMPs are used for alveolar bone regeneration [8, 13–15, 17, 30, 58], sinus lift augmentation [3, 5, 31, 61, 113], dental implants [16, 32], and periodontal [33–37] and dental regeneration [24–29]. The most prolific institution, with 5 publications, was Loma Linda University Medical Center, USA, followed by School of Medicine, University of California Los Angeles (UCLA), USA; Faculty of Dental Sciences, Kyushu University, Japan; Dental School, University of Zurich, Switzerland; School of Dentistry, Temple University, USA; and School of Dentistry, University of Michigan, USA, with 3 publications each. Bone Morphogenetic Protein. The evaluation of the scientific influence of journals assessed by bibliometrics is a multidimensional, complex construct, and hence, the utilization of a single bibliometric index is improper to assess, value, and rank journals. Bone morphogenetic protein-2 (BMP-2) is a potent growth factor affecting bone formation. Simple linear regression analysis of different journal metrics. The size of the node represents the frequency of the keywords, with larger nodes indicating higher frequency. Bone morphogenetic proteins /certified fixed orthodontic courses by Indian dental academy 1. Moreover, some publications might not be available in all these search engines [54, 66, 70, 71]. Chitosan/collagen scaffold containing bone morphogenetic protein‐7 DNA supports dental pulp stem cell differentiation in vitro and in vivo † Xuechao Yang Key Lab for Oral Biomedicine of Ministry of Education and Department of Endodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, People's Republic of China Furthermore, they are involved in the maintenance of various vital organs including the kidney, cartilage, muscle, bone, and blood vessels [10]. During surgery, the BMP is soaked onto and binds with a collagen sponge. Bone morphogenetic proteins: The anomalous molecules. An integrated analysis of clinical trials using the LT-CAGE lumbar tapered fusion device,”, J. K. Burkus, M. F. Gornet, C. A. Dickman, and T. A. Zdeblick, “Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages,”, R. W. Haid Jr., C. L. Branch Jr., J. T. Alexander, and J. K. Burkus, “Posterior lumbar interbody fusion using recombinant human bone morphogenetic protein type 2 with cylindrical interbody cages,”, P. V. Mummaneni, J. Pan, R. W. Haid, and G. E. Rodts, “Contribution of recombinant human bone morphogenetic protein—2 to the rapid creation of interbody fusion when used in transforaminal lumbar interbody fusion: a preliminary report. In-vitro studies have shown that rhBMP-2 can increase the proliferation of several multipotent cell lines, which can differentiate into osteoblasts, or bone-forming cells.3-7 However, the optimal coating methodology has not been clarified. Hence, publications regarding stem cells (927-14,575) [72], cardiology (331-3484) [73], head and neck oncology (628-3205) [74], and respirology (615-2918) [75] are more often cited than publications within dentistry (326-2050) [44], despite all these areas having equal scientific significance. The second-ranked article was also the RCT written by Jung et al., in 2003, with 16 citations [60]. Bone morphogenetic protein 9 (BMP9) is one of the most effective BMPs to induce the differentiation tem cells. Recombinant human bone morphogenetic protein-2 for peri-implant bone regeneration: A case report. %-------------------------------------------------------------------------------------------------- /Type /Font Huo, X. H. Pan, Q. Regarding the number of authors per publication, the average was 3.54, a lower average than other dental specialties including Periodontology with an average of 5.1 [79] or Implantology with an average of 4.66 [80] and much lower average than medical fields, for example, Cardiology with an average of 10.5 authors per article [81]. Furthermore, it is a fact that some authors may be inclined to cite the articles from a specific journal in which they intend to publish an article [115]. /Length 14214 Out of the top 50 most-cited publications, only 37 articles contained keywords. Bone morphogenetic protein works because it mimics the exact structure of the molecules that support bone growth in your body. Paras Ahmad, Elena Della Bella, Martin J. Stoddart, "Applications of Bone Morphogenetic Proteins in Dentistry: A Bibliometric Analysis", BioMed Research International, vol. The most prolific year was 1997 (). 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